Sources

Irinotecan Drug Labeling

• https://www.pharmgkb.org/label/PA166104831

Irinotecan Toxicity (dose decrease not supported)

• http://ascopubs.org/doi/abs/10.1200/JCO.2005.05.5400

Irinotecan Dosing

• http://ascopubs.org/doi/full/10.1200/jco.2014.55.2307
• https://www.researchgate.net/publication/263397222_Dose-Finding_and_Pharmacokinetic_Study_to_Optimize_the_Dosing_of_Irinotecan_According_to_the_UGT1A1_Genotype_of_Patients_With_Cancer

5-FU

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831181/

Fluorouracil Drug Label

• https://www.pharmgkb.org/label/PA166104807
• https://www.ncbi.nlm.nih.gov/pubmed/17015056

Paclitaxel

• https://academic.oup.com/annonc/article/24/6/1472/179298/CYP2C8-3-increases-risk-of-neuropathy-in-breast

Economic Impact Taxanes/Capecitabine

• http://www.ahdbonline.com/issues/2012/august-2012-vol-5-no-5-special-issue-asco-2012-payers-perspective/1079-article-1079

Capecitabine

• https://www.pharmgkb.org/guideline/PA166109594
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831181

Methotrexate

• https://www.fredhutch.org/en/news/releases/2001/06/MTHFR.html
• http://www.ascopost.com/issues/may-1-2014-supplement/methotrexate-and-fluorouracil-toxicities-a-collaborative-practice-approach-to-prevention-and-treatment
• http://www.bloodjournal.org/content/bloodjournal/98/1/231.full.pdf?sso-checked=true

Economics

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312207
• http://ar.iiarjournals.org/content/34/10/5241.full